Sauda Pdf  Download
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Habbatus sauda (Nigella sativa) had varieties of secondary metabolites with various activities, including as anticancer. Thymoquinone, one of them was known for its anticancer activity such as ER-positive and HER2-positive breast cancer. Besides, there were many other secondary metabolites which also had activity as anticancer compounds. This study aims to determine the most potent secondary metabolites of habbatus sauda as ER and HER2 inhibitor. The method used was molecular docking variety of habbatus sauda secondary metabolites against ER and HER2 receptors. The results obtained showed stigmasterol, a phytosterol provided most negative free energy of binding and lowest inhibition constants against both ER and HER2 receptors, with -10.85 kcal/mol and 11,12 nM for ER, also -12.64 and 0.54 nM for HER2, respectively. Stigmasterol showed higher affinity than thymoquinone towards ER and HER2 receptors. This results predicted that stigmasterol has activity as ER and HER2 inhibitor and should be potential to be developed as breast cancer therapy.
This diagram shows the basic flow/functionality of the sale module. This module consist near about all provision require for sale module. The first step start from Sauda booking in this case user can book sauda means contract of sale with the party, made a loading slip when product get loaded on vehicle then challan, Invoice and finally return against that hallan.
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As for testis parameters of rats treated with Habbatus sauda oil, findings in this research were in line with a report of increased number of spermatids in Nigella sativa-treated rats . Since thymoquinone is the major constituent found in Nigella sativa, it was believed to have protective effects on testicular parameters . In another study, the protective effects of thymoquinone on testicular parameters had been proven . In addition, coadministration of cisplatin and Nigella sativa oil on rats for a period of 21 days showed an evident improvement in the structure of testes . 2b1af7f3a8